Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function

Sara Becerril; Amaia Rodríguez; Victoria Catalán; Neira Sáinz; Beatriz Ramírez; María Collantes; Iván Peñuelas; Javier Gómez-Ambrosi; Gema Frühbeck

doi:10.1371/journal.pone.0010962

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Peer-reviewed

Research Article

Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function

Sara Becerril,

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
Amaia Rodríguez,

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
Victoria Catalán,

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
Neira Sáinz,

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
Beatriz Ramírez,

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
María Collantes,

Affiliation MicroPET Research Unit CIMA-CUN, University of Navarra, Pamplona, Spain
⨯
Iván Peñuelas,

Affiliation MicroPET Research Unit CIMA-CUN, University of Navarra, Pamplona, Spain
⨯
Javier Gómez-Ambrosi,

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
Gema Frühbeck

* E-mail: gfruhbeck@unav.es

Affiliations Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain, Department of Endocrinology, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯

Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function

Sara Becerril,
Amaia Rodríguez,
Victoria Catalán,
Neira Sáinz,
Beatriz Ramírez,
María Collantes,
Iván Peñuelas,
Javier Gómez-Ambrosi,
Gema Frühbeck

Published: June 4, 2010
https://doi.org/10.1371/journal.pone.0010962

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Brown adipose tissue
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Bioenergetics
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Gene expression
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Adipocytes
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Leptin
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