Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain

Matthew S. Alkaitis; Carlos Solorzano; Russell P. Landry; Daniele Piomelli; Joyce A. DeLeo; E. Alfonso Romero-Sandoval

doi:10.1371/journal.pone.0010891

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Research Article

Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain

Matthew S. Alkaitis,

Affiliations Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom
⨯
Carlos Solorzano,

Affiliation Departments of Pharmacology and Biological Chemistry, University of California Irvine, Irvine, California, United States of America
⨯
Russell P. Landry,

Affiliations Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, Department of Anesthesiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
⨯
Daniele Piomelli,

Affiliation Departments of Pharmacology and Biological Chemistry, University of California Irvine, Irvine, California, United States of America
⨯
Joyce A. DeLeo,

Affiliations Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, Department of Anesthesiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
⨯
E. Alfonso Romero-Sandoval

* E-mail: Edgar.A.Romero-Sandoval@dartmouth.edu

Affiliations Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, Department of Anesthesiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
⨯

Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain

Matthew S. Alkaitis,
Carlos Solorzano,
Russell P. Landry,
Daniele Piomelli,
Joyce A. DeLeo,
E. Alfonso Romero-Sandoval

Published: May 28, 2010
https://doi.org/10.1371/journal.pone.0010891

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Surgical and invasive medical procedures
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Pain
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Receptor antagonist therapy
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Spinal cord
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