Fluorescence-Tracking of Activation Gating in Human ERG Channels Reveals Rapid S4 Movement and Slow Pore Opening

Open Access

Peer-reviewed

Research Article

Zeineb Es-Salah-Lamoureux ,

Contributed equally to this work with: Zeineb Es-Salah-Lamoureux, Robert Fougere

Affiliation Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
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Robert Fougere ,

Contributed equally to this work with: Zeineb Es-Salah-Lamoureux, Robert Fougere

Affiliation Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Ping Yu Xiong,

Affiliation Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
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Gail A. Robertson,

Affiliation Department of Physiology, University of Wisconsin-Madison School of Medicine, Madison, Wisconsin, United States of America
⨯
David Fedida

* E-mail: fedida@interchange.ubc.ca

Affiliation Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
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Cysteine
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Membrane potential
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Fluorescence
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Potassium channels
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