Targeted Mutation of the Mouse Grp94 Gene Disrupts Development and Perturbs Endoplasmic Reticulum Stress Signaling

• Changhui Mao ,

  Contributed equally to this work with: Changhui Mao, Miao Wang, Biquan Luo

  Current address: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Miao Wang ,

  Contributed equally to this work with: Changhui Mao, Miao Wang, Biquan Luo

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Biquan Luo ,

  Contributed equally to this work with: Changhui Mao, Miao Wang, Biquan Luo

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Shiuan Wey,

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Dezheng Dong,

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Robin Wesselschmidt,

  Current address: Primogenix, Inc., Laurie, Missouri, United States of America

  Affiliation Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Stephen Rawlings,

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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• Amy S. Lee

  * E-mail: amylee@ccnt.usc.edu

  Affiliation Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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