Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

Masayuki Nitta; David Kozono; Richard Kennedy; Jayne Stommel; Kimberly Ng; Pascal O. Zinn; Deepa Kushwaha; Santosh Kesari; Frank Furnari; Katherine A. Hoadley; Lynda Chin; Ronald A. DePinho; Webster K. Cavenee; Alan D'Andrea; Clark C. Chen

doi:10.1371/journal.pone.0010767

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Open Access

Peer-reviewed

Research Article

Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

Masayuki Nitta ,

Contributed equally to this work with: Masayuki Nitta, David Kozono

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
David Kozono ,

Contributed equally to this work with: Masayuki Nitta, David Kozono

Affiliations Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Radiation Oncology Program, Boston, Massachusetts, United States of America
⨯
Richard Kennedy,

Affiliation Almac Diagnostics, Craigavon, Northern Ireland, United Kingdom
⨯
Jayne Stommel,

Affiliation Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Kimberly Ng,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Pascal O. Zinn,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Deepa Kushwaha,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Santosh Kesari,

Affiliation Department of Neurology, Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America
⨯
Frank Furnari,

Affiliation San Diego Branch, Ludwig Institute for Cancer Research, La Jolla, California, United States of America
⨯
Katherine A. Hoadley,

Affiliation Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Lynda Chin,

Affiliation Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Ronald A. DePinho,

Affiliation Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Webster K. Cavenee,

Affiliation San Diego Branch, Ludwig Institute for Cancer Research, La Jolla, California, United States of America
⨯
Alan D'Andrea,

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Clark C. Chen

* E-mail: clark_chen@dfci.harvard.edu

Affiliations Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯

Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

Masayuki Nitta,
David Kozono,
Richard Kennedy,
Jayne Stommel,
Kimberly Ng,
Pascal O. Zinn,
Deepa Kushwaha,
Santosh Kesari,
Frank Furnari,
Katherine A. Hoadley

Published: May 24, 2010
https://doi.org/10.1371/journal.pone.0010767

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