Transcription-Associated Mutagenesis Increases Protein Sequence Diversity More Effectively than Does Random Mutagenesis in Escherichia coli

Open Access

Peer-reviewed

Research Article

Hyunchul Kim,

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan, Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Japan
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Baek-Seok Lee,

Current address: R&D Center for Bioproducts, CJ Corporation, Seoul, Korea

Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan
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Masaru Tomita,

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan, Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Japan
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Akio Kanai

* E-mail: akio@sfc.keio.ac.jp

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan, Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Japan
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Substitution mutation
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Mutagenesis
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Control sequences
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DNA transcription
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Nonsense mutation
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Gene knockout
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Silent mutation
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Missense mutation
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