Integrin-Blocking Antibodies Delay Keratinocyte Re-Epithelialization in a Human Three-Dimensional Wound Healing Model

Christophe Egles; Heather A. Huet; Furkan Dogan; Sam Cho; Shumin Dong; Avi Smith; Elana B. Knight; Karen R. McLachlan; Jonathan A. Garlick

doi:10.1371/journal.pone.0010528

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Open Access

Peer-reviewed

Research Article

Integrin-Blocking Antibodies Delay Keratinocyte Re-Epithelialization in a Human Three-Dimensional Wound Healing Model

Christophe Egles ,

* E-mail: Christophe.egles@tufts.edu

Affiliation Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, United States of America
⨯
Heather A. Huet,

Affiliation Discovery Oncobiology, Biogen Idec, Cambridge, Massachusetts, United States of America
⨯
Furkan Dogan,

Affiliation Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, United States of America
⨯
Sam Cho,

Affiliation Translational Oncobiology, Biogen Idec, San Diego, California, United States of America
⨯
Shumin Dong,

Affiliation Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, United States of America
⨯
Avi Smith,

Affiliation Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, United States of America
⨯
Elana B. Knight,

Affiliation Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, United States of America
⨯
Karen R. McLachlan,

Affiliation Translational Oncobiology, Biogen Idec, San Diego, California, United States of America
⨯
Jonathan A. Garlick

Affiliation Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, United States of America
⨯

Integrin-Blocking Antibodies Delay Keratinocyte Re-Epithelialization in a Human Three-Dimensional Wound Healing Model

Christophe Egles,
Heather A. Huet,
Furkan Dogan,
Sam Cho,
Shumin Dong,
Avi Smith,
Elana B. Knight,
Karen R. McLachlan,
Jonathan A. Garlick

Published: May 21, 2010
https://doi.org/10.1371/journal.pone.0010528

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Keratinocytes
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Integrins
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Basement membrane
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Wound healing
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Antibody therapy
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Flow cytometry
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Collagens
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Skin
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