A Novel Synthetic Analog of 5, 8-Disubstituted Quinazolines Blocks Mitosis and Induces Apoptosis of Tumor Cells by Inhibiting Microtubule Polymerization

Open Access

Peer-reviewed

Research Article

Wei Tian,

Affiliation The School of Life Science and Biopharmaceutics of Shenyang Pharmaceutical University, Liaoning, China
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Lili Qin,

Affiliation The School of Life Science and Biopharmaceutics of Shenyang Pharmaceutical University, Liaoning, China
⨯
Qiaoling Song,

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Li He,

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Midan Ai,

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Yi Jin,

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Zuyu Zhou,

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Song You,

Affiliation The School of Life Science and Biopharmaceutics of Shenyang Pharmaceutical University, Liaoning, China
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Yaqiu Long,

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Qiang Yu

* E-mail: qyu@sibs.ac.cn

Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
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Colchicine
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Microtubules
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Apoptosis
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Cancer treatment
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Mitosis
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Microtubule polymerization
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Tubulins
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MTT assay
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