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Open Access

Peer-reviewed

Research Article

HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

Kalpana Ghoshal ,

* E-mail: samson.jacob@osumc.edu (STJ); kalpana.ghoshal@osumc.edu (KG)

Affiliations Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
⨯
Tasneem Motiwala,

Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
⨯
Rainer Claus,

Affiliation Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
⨯
Pearlly Yan,

Affiliations Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America
⨯
Huban Kutay,

Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
⨯
Jharna Datta,

Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
⨯
Sarmila Majumder,

Affiliations Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
⨯
Shoumei Bai,

Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
⨯
Arnab Majumder,

Affiliation Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
⨯
Tim Huang,

Affiliations Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America
⨯
Christoph Plass,

Affiliation Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
⨯
Samson T. Jacob

* E-mail: samson.jacob@osumc.edu (STJ); kalpana.ghoshal@osumc.edu (KG)

Affiliations Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
⨯

HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

Kalpana Ghoshal,
Tasneem Motiwala,
Rainer Claus,
Pearlly Yan,
Huban Kutay,
Jharna Datta,
Sarmila Majumder,
Shoumei Bai,
Arnab Majumder,
Tim Huang

x

Published: April 29, 2010
https://doi.org/10.1371/journal.pone.0010338

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DNA methylation
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Colorectal cancer
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Homeobox
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Immunoprecipitation
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Tumor suppressor genes
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Breast cancer
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Colon
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Renal cancer
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