Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

Madhuri Salker; Gijs Teklenburg; Mariam Molokhia; Stuart Lavery; Geoffrey Trew; Tepchongchit Aojanepong; Helen J. Mardon; Amali U. Lokugamage; Raj Rai; Christian Landles; Bernard A. J. Roelen; Siobhan Quenby; Ewart W. Kuijk; Annemieke Kavelaars; Cobi J. Heijnen; Lesley Regan; Nick S. Macklon; Jan J. Brosens

doi:10.1371/journal.pone.0010287

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Peer-reviewed

Research Article

Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

Madhuri Salker,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Gijs Teklenburg,

Affiliations Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Mariam Molokhia,

Affiliation Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
⨯
Stuart Lavery,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Geoffrey Trew,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Tepchongchit Aojanepong,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Helen J. Mardon,

Affiliation Nuffield Department of Obstetrics and Gynecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Amali U. Lokugamage,

Affiliation Department of Obstetrics and Gynecology, the Whittington Hospital NHS Trust, London, United Kingdom
⨯
Raj Rai,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Christian Landles,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Bernard A. J. Roelen,

Affiliation Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Siobhan Quenby,

Affiliation Department of Reproductive and Developmental Health, Liverpool Women's Hospital, University of Liverpool, Liverpool, United Kingdom
⨯
Ewart W. Kuijk,

Affiliation Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Annemieke Kavelaars,

Affiliation Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Cobi J. Heijnen,

Affiliation Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Lesley Regan,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Nick S. Macklon,

Affiliations Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands, Division of Developmental Origins of Health and Disease, Princess Anne Hospital, University of Southampton, Southampton, United Kingdom
⨯
[ ... ],
Jan J. Brosens

* E-mail: j.brosens@imperial.ac.uk

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
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Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

Madhuri Salker,
Gijs Teklenburg,
Mariam Molokhia,
Stuart Lavery,
Geoffrey Trew,
Tepchongchit Aojanepong,
Helen J. Mardon,
Amali U. Lokugamage,
Raj Rai,
Christian Landles

Published: April 21, 2010
https://doi.org/10.1371/journal.pone.0010287

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Pregnancy
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Embryos
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Miscarriage
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Medical implants
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Biopsy
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Cell differentiation
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Messenger RNA
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