Extracellular SOD-Derived H2O2 Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

Jin Oshikawa; Norifumi Urao; Ha Won Kim; Nihal Kaplan; Masooma Razvi; Ronald McKinney; Leslie B. Poole; Tohru Fukai; Masuko Ushio-Fukai

doi:10.1371/journal.pone.0010189

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Research Article

Extracellular SOD-Derived H₂O₂ Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

Jin Oshikawa,

Affiliations Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Norifumi Urao,

Affiliations Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Ha Won Kim,

Affiliations Department of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Nihal Kaplan,

Affiliations Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Masooma Razvi,

Affiliations Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Ronald McKinney,

Affiliations Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Leslie B. Poole,

Affiliation Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Tohru Fukai,

Affiliations Department of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Masuko Ushio-Fukai

* E-mail: mfukai@uic.edu

Affiliations Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯

Extracellular SOD-Derived H₂O₂ Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

Jin Oshikawa,
Norifumi Urao,
Ha Won Kim,
Nihal Kaplan,
Masooma Razvi,
Ronald McKinney,
Leslie B. Poole,
Tohru Fukai,
Masuko Ushio-Fukai

Published: April 21, 2010
https://doi.org/10.1371/journal.pone.0010189

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Angiogenesis
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VEGF signaling
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Lipids
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