Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase

Zhiyong Ding; Jiyong Liang; Jin Li; Yiling Lu; Vathsala Ariyaratna; Zhimin Lu; Michael A. Davies; John K. Westwick; Gordon B. Mills

doi:10.1371/journal.pone.0009910

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Peer-reviewed

Research Article

Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase

Zhiyong Ding ,

* E-mail: zding@mdanderson.org

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jiyong Liang,

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jin Li,

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yiling Lu,

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Vathsala Ariyaratna,

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zhimin Lu,

Affiliation Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Michael A. Davies,

Affiliations Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America, Department of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
John K. Westwick,

Affiliation Odyssey Thera, Inc., San Ramon, California, United States of America
⨯
Gordon B. Mills

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯

Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase

Zhiyong Ding,
Jiyong Liang,
Jin Li,
Yiling Lu,
Vathsala Ariyaratna,
Zhimin Lu,
Michael A. Davies,
John K. Westwick,
Gordon B. Mills

Published: March 26, 2010
https://doi.org/10.1371/journal.pone.0009910

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