Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

Shinji Hadano; Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Akira Akatsuka; Masato Koike; Masashi Aoki; Yasuo Uchiyama; Yasuto Itoyama; Joh-E Ikeda

doi:10.1371/journal.pone.0009805

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Open Access

Peer-reviewed

Research Article

Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1^H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

Shinji Hadano ,

* E-mail: shinji@is.icc.u-tokai.ac.jp (SH); jei@m.med.u-tokai.ac.jp (JEI)

Affiliations Neurodegenerative Diseases Research Centre, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, Japan, Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan, The Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan
⨯
Asako Otomo,

Affiliation Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Ryota Kunita,

Affiliation Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Kyoko Suzuki-Utsunomiya,

Affiliation Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan
⨯
Akira Akatsuka,

Affiliation Teaching and Research Support Center, Tokai University, Isehara, Kanagawa, Japan
⨯
Masato Koike,

Affiliation Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
⨯
Masashi Aoki,

Affiliation Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
⨯
Yasuo Uchiyama,

Affiliation Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
⨯
Yasuto Itoyama,

Affiliation Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
⨯
Joh-E Ikeda

* E-mail: shinji@is.icc.u-tokai.ac.jp (SH); jei@m.med.u-tokai.ac.jp (JEI)

Affiliations Neurodegenerative Diseases Research Centre, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, Japan, Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan, The Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan, Apoptosis Research Centre, Children Hospital of Eastern Ontario, Ottawa, Ontario, Canada
⨯

Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1^H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

Shinji Hadano,
Asako Otomo,
Ryota Kunita,
Kyoko Suzuki-Utsunomiya,
Akira Akatsuka,
Masato Koike,
Masashi Aoki,
Yasuo Uchiyama,
Yasuto Itoyama,
Joh-E Ikeda

Published: March 22, 2010
https://doi.org/10.1371/journal.pone.0009805

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