A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control

Scott B. Widenmaier; Su-Jin Kim; Gary K. Yang; Thomas De Los Reyes; Cuilan Nian; Ali Asadi; Yutaka Seino; Timothy J. Kieffer; Yin Nam Kwok; Christopher H. S. McIntosh

doi:10.1371/journal.pone.0009590

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Open Access

Peer-reviewed

Research Article

A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control

Scott B. Widenmaier,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Su-Jin Kim,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Gary K. Yang,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Thomas De Los Reyes,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Cuilan Nian,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Ali Asadi,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Yutaka Seino,

Affiliation Department of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital, Osaka, Japan
⨯
Timothy J. Kieffer,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Yin Nam Kwok,

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Christopher H. S. McIntosh

* E-mail: mcintoch@interchange.ubc.ca

Affiliation Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
⨯

A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control

Scott B. Widenmaier,
Su-Jin Kim,
Gary K. Yang,
Thomas De Los Reyes,
Cuilan Nian,
Ali Asadi,
Yutaka Seino,
Timothy J. Kieffer,
Yin Nam Kwok,
Christopher H. S. McIntosh

Published: March 9, 2010
https://doi.org/10.1371/journal.pone.0009590

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