Endothelial Cell Processing and Alternatively Spliced Transcripts of Factor VIII: Potential Implications for Coagulation Cascades and Pulmonary Hypertension

Claire L. Shovlin; Gillian Angus; Richard A. Manning; Grace N. Okoli; Fatima S. Govani; Kay Elderfield; Graeme M. Birdsey; Inês G. Mollet; Michael A. Laffan; Francesco A. Mauri

doi:10.1371/journal.pone.0009154

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Open Access

Peer-reviewed

Research Article

Endothelial Cell Processing and Alternatively Spliced Transcripts of Factor VIII: Potential Implications for Coagulation Cascades and Pulmonary Hypertension

Claire L. Shovlin ,

* E-mail: c.shovlin@imperial.ac.uk

Affiliations National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, London, United Kingdom, Respiratory Medicine, Imperial College Healthcare National Health Services Trust, London, United Kingdom
⨯
Gillian Angus,

Affiliation Haematology, Imperial College Healthcare National Health Services Trust, London, United Kingdom
⨯
Richard A. Manning,

Affiliation Haematology, Imperial College Healthcare National Health Services Trust, London, United Kingdom
⨯
Grace N. Okoli,

Affiliation National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, London, United Kingdom
⨯
Fatima S. Govani,

Affiliation National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, London, United Kingdom
⨯
Kay Elderfield,

Affiliation Histopathology, Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Graeme M. Birdsey,

Affiliation National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, London, United Kingdom
⨯
Inês G. Mollet,

Affiliation Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
⨯
Michael A. Laffan,

Affiliations Investigative Sciences, Imperial College London, London, United Kingdom, Haematology, Imperial College Healthcare National Health Services Trust, London, United Kingdom
⨯
Francesco A. Mauri

Affiliation Histopathology, Imperial College Healthcare NHS Trust, London, United Kingdom
⨯

Endothelial Cell Processing and Alternatively Spliced Transcripts of Factor VIII: Potential Implications for Coagulation Cascades and Pulmonary Hypertension

Claire L. Shovlin,
Gillian Angus,
Richard A. Manning,
Grace N. Okoli,
Fatima S. Govani,
Kay Elderfield,
Graeme M. Birdsey,
Inês G. Mollet,
Michael A. Laffan,
Francesco A. Mauri

Published: February 11, 2010
https://doi.org/10.1371/journal.pone.0009154

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Endothelial cells
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Blood plasma
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Pulmonary hypertension
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Enzyme-linked immunoassays
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Fluorescence imaging
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Imaging techniques
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Alternative splicing
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Pulmonary arteries
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