Telomere Shortening Sensitizes Cancer Cells to Selected Cytotoxic Agents: In Vitro and In Vivo Studies and Putative Mechanisms

Orit Uziel; Einat Beery; Vladimir Dronichev; Katty Samocha; Sergei Gryaznov; Lola Weiss; Shimon Slavin; Michal Kushnir; Yardena Nordenberg; Claudette Rabinowitz; Baruch Rinkevich; Tania Zehavi; Meir Lahav

doi:10.1371/journal.pone.0009132

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Open Access

Peer-reviewed

Research Article

Telomere Shortening Sensitizes Cancer Cells to Selected Cytotoxic Agents: In Vitro and In Vivo Studies and Putative Mechanisms

Orit Uziel,

Affiliation Beilinson Hospital, Rabin Medical Center, Felsenstein Medical Research Center, Petah-Tikva, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Einat Beery,

Affiliation Beilinson Hospital, Rabin Medical Center, Felsenstein Medical Research Center, Petah-Tikva, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Vladimir Dronichev,

Affiliation Beilinson Hospital, Rabin Medical Center, Felsenstein Medical Research Center, Petah-Tikva, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Katty Samocha,

Affiliation Beilinson Hospital, Rabin Medical Center, Felsenstein Medical Research Center, Petah-Tikva, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Sergei Gryaznov,

Affiliation Geron Corporation, Menlo Park, California, United States of America
⨯
Lola Weiss,

Affiliation Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital, Jerusalem, Israel
⨯
Shimon Slavin,

Affiliation Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital, Jerusalem, Israel
⨯
Michal Kushnir,

Affiliation Rosetta Genomics Ltd, Rehovot, Israel
⨯
Yardena Nordenberg,

Affiliation Beilinson Hospital, Rabin Medical Center, Felsenstein Medical Research Center, Petah-Tikva, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Claudette Rabinowitz,

Affiliation National Institute of Oceanography, Haifa, Israel
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Baruch Rinkevich,

Affiliation National Institute of Oceanography, Haifa, Israel
⨯
Tania Zehavi,

Affiliation Department of Pathology, Meir Medical Center, Kfar-Saba, Israel
⨯
Meir Lahav

* E-mail: mlahav@post.tau.ac.il

Affiliation Beilinson Hospital, Rabin Medical Center, Felsenstein Medical Research Center, Petah-Tikva, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯

Telomere Shortening Sensitizes Cancer Cells to Selected Cytotoxic Agents: In Vitro and In Vivo Studies and Putative Mechanisms

Orit Uziel,
Einat Beery,
Vladimir Dronichev,
Katty Samocha,
Sergei Gryaznov,
Lola Weiss,
Shimon Slavin,
Michal Kushnir,
Yardena Nordenberg,
Claudette Rabinowitz

Published: February 9, 2010
https://doi.org/10.1371/journal.pone.0009132

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Telomeres
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DNA damage
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Cancer treatment
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Telomere length
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Malignant tumors
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Cancers and neoplasms
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DNA repair
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Lung and intrathoracic tumors
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