A Novel Method to Adjust Efficacy Estimates for Uptake of Other Active Treatments in Long-Term Clinical Trials

• John Simes ,

  * E-mail: john@ctc.usyd.edu.au

  Affiliation National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia

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• Merryn Voysey,

  Affiliation National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia

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• Rachel O'Connell,

  Affiliation National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia

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• Paul Glasziou,

  Affiliation Centre for Evidence-Based Medicine, University of Oxford, Oxford, United Kingdom

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• James D. Best,

  Affiliation Faculty of Medicine, University of Melbourne, Melbourne, Australia

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• Russell Scott,

  Affiliation Lipid and Diabetes Research Group, Christchurch Hospital, Christchurch, New Zealand

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• Christopher Pardy,

  Affiliation National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia

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• Karen Byth,

  Affiliation National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia

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• David R. Sullivan,

  Affiliation Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia

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• Christian Ehnholm,

  Affiliation Biomedicum Helsinki, National Public Health Institutes, Helsinki, Finland

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• Anthony Keech,

  Affiliation National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia

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• for the FIELD Study Investigators