Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

Open Access

Peer-reviewed

Research Article

Matthew L. Hemming,

Affiliation Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joshua E. Elias,

Current address: Department of Chemical and Systems Biology, Stanford School of Medicine, Stanford, California, United States of America

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Steven P. Gygi,

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Dennis J. Selkoe

* E-mail: dselkoe@rics.bwh.harvard.edu

Affiliation Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯

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Integral membrane proteins
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Molting
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Membrane proteins
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HEK 293 cells
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Metalloproteases
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Proteases
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Lipoprotein receptors
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Proteomics
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