Global Demethylation of Rat Chondrosarcoma Cells after Treatment with 5-Aza-2′-Deoxycytidine Results in Increased Tumorigenicity

Christopher A. Hamm; Hehuang Xie; Fabricio F. Costa; Elio F. Vanin; Elisabeth A. Seftor; Simone T. Sredni; Jared Bischof; Deli Wang; Maria F. Bonaldo; Mary J. C. Hendrix; Marcelo B. Soares

doi:10.1371/journal.pone.0008340

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Open Access

Peer-reviewed

Research Article

Global Demethylation of Rat Chondrosarcoma Cells after Treatment with 5-Aza-2′-Deoxycytidine Results in Increased Tumorigenicity

Christopher A. Hamm,

Affiliations Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, Iowa, United States of America, Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America
⨯
Hehuang Xie,

Affiliations Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Fabricio F. Costa,

Affiliation Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America
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Elio F. Vanin,

Affiliation Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America
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Elisabeth A. Seftor,

Affiliation Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America
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Simone T. Sredni,

Affiliation Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America
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Jared Bischof,

Affiliation Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America
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Deli Wang,

Affiliation Biostatistics Research Core, Children's Memorial Research Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United states of America
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Maria F. Bonaldo,

Affiliations Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Mary J. C. Hendrix,

Affiliations Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United States of America
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Marcelo B. Soares

* E-mail: mbsoares@childrensmemorial.org

Affiliations Cancer Biology and Epigenomics Program, Falk Brain Tumor Center, Children's Memorial Research Center, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯

Global Demethylation of Rat Chondrosarcoma Cells after Treatment with 5-Aza-2′-Deoxycytidine Results in Increased Tumorigenicity

Christopher A. Hamm,
Hehuang Xie,
Fabricio F. Costa,
Elio F. Vanin,
Elisabeth A. Seftor,
Simone T. Sredni,
Jared Bischof,
Deli Wang,
Maria F. Bonaldo,
Mary J. C. Hendrix

Published: December 17, 2009
https://doi.org/10.1371/journal.pone.0008340

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DNA methylation
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