Eukaryotic Initiation Factor 2B (eIF2B) GEF Activity as a Diagnostic Tool for EIF2B-Related Disorders

Laetitia Horzinski; Aurélia Huyghe; Marie-Céleste Cardoso; Céline Gonthier; Lemlih Ouchchane; Raphael Schiffmann; Pierre Blanc; Odile Boespflug-Tanguy; Anne Fogli

doi:10.1371/journal.pone.0008318

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Open Access

Peer-reviewed

Research Article

Eukaryotic Initiation Factor 2B (eIF2B) GEF Activity as a Diagnostic Tool for EIF2B-Related Disorders

Laetitia Horzinski,

Affiliations INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France, Université Clermont 1, UFR Médecine, Clermont-Ferrand, France
⨯
Aurélia Huyghe,

Affiliations INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France, Université Clermont 1, UFR Médecine, Clermont-Ferrand, France
⨯
Marie-Céleste Cardoso,

Affiliations INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France, Université Clermont 1, UFR Médecine, Clermont-Ferrand, France, CHU de Clermont-Ferrand, Service de Biochimie Médicale et Biologie Moléculaire, Clermont-Ferrand, France
⨯
Céline Gonthier,

Affiliation INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France
⨯
Lemlih Ouchchane,

Affiliations Université de Clermont, UFR Médecine, EA3295, Equipe de Recherche en signal et Imagerie Médicale, Clermont-Ferrand, France, CHU de Clermont-Ferrand, Hôpital Gabriel Montpied, Laboratoire de Biostatistiques, Télématique et Traitement d'Images, Clermont-Ferrand, France
⨯
Raphael Schiffmann,

Affiliation Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas, United States of America
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Pierre Blanc,

Affiliations INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France, CHU de Clermont-Ferrand, Service de Biochimie Médicale et Biologie Moléculaire, Clermont-Ferrand, France
⨯
Odile Boespflug-Tanguy,

Affiliations INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France, Université Clermont 1, UFR Médecine, Clermont-Ferrand, France, CHU de Clermont-Ferrand, Service de Génétique Médicale, Centre de Référence Leucodystrophies, Hôpital Hôtel-Dieu, Clermont-Ferrand, France
⨯
Anne Fogli

* E-mail: anne.fogli@inserm.u-clermont1.fr

Affiliations INSERM U931-CNRS 6247- Université Clermont, GReD, Clermont-Ferrand, France, Université Clermont 1, UFR Médecine, Clermont-Ferrand, France, CHU de Clermont-Ferrand, Service de Biochimie Médicale et Biologie Moléculaire, Clermont-Ferrand, France
⨯

Eukaryotic Initiation Factor 2B (eIF2B) GEF Activity as a Diagnostic Tool for EIF2B-Related Disorders

Laetitia Horzinski,
Aurélia Huyghe,
Marie-Céleste Cardoso,
Céline Gonthier,
Lemlih Ouchchane,
Raphael Schiffmann,
Pierre Blanc,
Odile Boespflug-Tanguy,
Anne Fogli

Published: December 15, 2009
https://doi.org/10.1371/journal.pone.0008318

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