Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

Andrea Perne; Markus K. Muellner; Magdalena Steinrueck; Nils Craig-Mueller; Julia Mayerhofer; Ilse Schwarzinger; Mathew Sloane; Iris Z. Uras; Gregor Hoermann; Sebastian M. B. Nijman; Matthias Mayerhofer

doi:10.1371/journal.pone.0008292

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Open Access

Peer-reviewed

Research Article

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

Andrea Perne ,

Contributed equally to this work with: Andrea Perne, Markus K. Muellner

Affiliation Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
⨯
Markus K. Muellner ,

Contributed equally to this work with: Andrea Perne, Markus K. Muellner

Affiliation Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria
⨯
Magdalena Steinrueck,

Affiliation Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
⨯
Nils Craig-Mueller,

Affiliation Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria
⨯
Julia Mayerhofer,

Affiliation Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
⨯
Ilse Schwarzinger,

Affiliation Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
⨯
Mathew Sloane,

Affiliation Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria
⨯
Iris Z. Uras,

Affiliation Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria
⨯
Gregor Hoermann,

Affiliation Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
⨯
Sebastian M. B. Nijman ,

* E-mail: snijman@cemm.oeaw.at (SMBN); matthias.mayerhofer@meduniwien.ac.at (MM)

¶These authors also contributed equally to this work.

Affiliation Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria
⨯
Matthias Mayerhofer

* E-mail: snijman@cemm.oeaw.at (SMBN); matthias.mayerhofer@meduniwien.ac.at (MM)

¶These authors also contributed equally to this work.

Affiliation Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
⨯

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

Andrea Perne,
Markus K. Muellner,
Magdalena Steinrueck,
Nils Craig-Mueller,
Julia Mayerhofer,
Ilse Schwarzinger,
Mathew Sloane,
Iris Z. Uras,
Gregor Hoermann,
Sebastian M. B. Nijman

Published: December 16, 2009
https://doi.org/10.1371/journal.pone.0008292

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Protein synthesis
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Cancer treatment
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Glycosides
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Protein synthesis inhibitors
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