Vitamin B12-Impaired Metabolism Produces Apoptosis and Parkinson Phenotype in Rats Expressing the Transcobalamin-Oleosin Chimera in Substantia Nigra

Carlos Enrique Orozco-Barrios; Shyue-Fang Battaglia-Hsu; Martha Ligia Arango-Rodriguez; Jose Ayala-Davila; Celine Chery; Jean-Marc Alberto; Henry Schroeder; Jean-Luc Daval; Daniel Martinez-Fong; Jean-Louis Gueant

doi:10.1371/journal.pone.0008268

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Research Article

Vitamin B12-Impaired Metabolism Produces Apoptosis and Parkinson Phenotype in Rats Expressing the Transcobalamin-Oleosin Chimera in Substantia Nigra

Carlos Enrique Orozco-Barrios,

Affiliations Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico, Inserm U954, Faculté de Médecine, Nancy-Université, Nancy, France
⨯
Shyue-Fang Battaglia-Hsu,

Affiliation Inserm U954, Faculté de Médecine, Nancy-Université, Nancy, France
⨯
Martha Ligia Arango-Rodriguez,

Affiliation Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico
⨯
Jose Ayala-Davila,

Affiliation Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico
⨯
Celine Chery,

Affiliation Inserm U954, Faculté de Médecine, Nancy-Université, Nancy, France
⨯
Jean-Marc Alberto,

Affiliation Inserm U954, Faculté de Médecine, Nancy-Université, Nancy, France
⨯
Henry Schroeder,

Affiliation Institut national de la recherche agronomique (INRA), URAFPA, Nancy-Université, Nancy, France
⨯
Jean-Luc Daval,

Affiliation Inserm U954, Faculté de Médecine, Nancy-Université, Nancy, France
⨯
Daniel Martinez-Fong ,

Contributed equally to this work with: Daniel Martinez-Fong, Jean-Louis Gueant

Affiliation Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico
⨯
Jean-Louis Gueant

Contributed equally to this work with: Daniel Martinez-Fong, Jean-Louis Gueant

* E-mail: jean-louis.gueant@medecine.uhp-nancy.fr

Affiliation Inserm U954, Faculté de Médecine, Nancy-Université, Nancy, France
⨯

Vitamin B12-Impaired Metabolism Produces Apoptosis and Parkinson Phenotype in Rats Expressing the Transcobalamin-Oleosin Chimera in Substantia Nigra

Carlos Enrique Orozco-Barrios,
Shyue-Fang Battaglia-Hsu,
Martha Ligia Arango-Rodriguez,
Jose Ayala-Davila,
Celine Chery,
Jean-Marc Alberto,
Henry Schroeder,
Jean-Luc Daval,
Daniel Martinez-Fong,
Jean-Louis Gueant

Published: December 21, 2009
https://doi.org/10.1371/journal.pone.0008268

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Transfection
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Substantia nigra
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Apoptosis
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Cobalamins
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Vitamin B12 deficiency
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