Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin

Thibaut Quillard; Julie Devalliere; Mathias Chatelais; Flora Coulon; Céline Séveno; Mathilde Romagnoli; Sophie Barillé Nion; Béatrice Charreau

doi:10.1371/journal.pone.0008244

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Open Access

Peer-reviewed

Research Article

Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin

Thibaut Quillard,

Current address: Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Affiliations INSERM, UMR643, Nantes, France, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France, Université de Nantes, Faculté de Médecine, Nantes, France
⨯
Julie Devalliere,

Affiliations INSERM, UMR643, Nantes, France, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France, Université de Nantes, Faculté de Médecine, Nantes, France
⨯
Mathias Chatelais,

Affiliations INSERM, UMR643, Nantes, France, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France, Université de Nantes, Faculté de Médecine, Nantes, France
⨯
Flora Coulon,

Affiliations INSERM, UMR643, Nantes, France, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France, Université de Nantes, Faculté de Médecine, Nantes, France
⨯
Céline Séveno,

Affiliation INSERM, UMR 892, Nantes, France
⨯
Mathilde Romagnoli,

Current address: Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America

Affiliation INSERM, UMR 892, Nantes, France
⨯
Sophie Barillé Nion,

Affiliation INSERM, UMR 892, Nantes, France
⨯
Béatrice Charreau

* E-mail: Beatrice.Charreau@univ-nantes.fr

Affiliations INSERM, UMR643, Nantes, France, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France, Université de Nantes, Faculté de Médecine, Nantes, France
⨯

Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin

Thibaut Quillard,
Julie Devalliere,
Mathias Chatelais,
Flora Coulon,
Céline Séveno,
Mathilde Romagnoli,
Sophie Barillé Nion,
Béatrice Charreau

Published: December 11, 2009
https://doi.org/10.1371/journal.pone.0008244

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Apoptosis
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Notch signaling
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Transfection
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Small interfering RNA
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Cytokines
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Endothelial cells
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Inflammation
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Gene expression
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