Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

Matthew N. Davies; Jagadeesh Bayry; Elma Z. Tchilian; Janakiraman Vani; Melkote S. Shaila; Emily K. Forbes; Simon J. Draper; Peter C. L. Beverley; David F. Tough; Darren R. Flower

doi:10.1371/journal.pone.0008084

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Open Access

Peer-reviewed

Research Article

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

Matthew N. Davies,

Current address: Institute of Psychiatry, King's College London, London, United Kingdom

Affiliation The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom
⨯
Jagadeesh Bayry,

Affiliations The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom, Institut National de la Santé et de la Recherche Médicale Unité 872, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Unité Mixte de Recherche en Santé 872/Université Paris Descartes - Unité Mixte de Recherche en Santé 872, Paris, France
⨯
Elma Z. Tchilian,

Affiliation The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
Janakiraman Vani,

Affiliation Institut National de la Santé et de la Recherche Médicale Unité 872, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Unité Mixte de Recherche en Santé 872/Université Paris Descartes - Unité Mixte de Recherche en Santé 872, Paris, France
⨯
Melkote S. Shaila,

Affiliation Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
⨯
Emily K. Forbes,

Affiliation The Jenner Institute, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
Simon J. Draper,

Affiliation The Jenner Institute, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
Peter C. L. Beverley,

Affiliation The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, Oxfordshire, United Kingdom
⨯
David F. Tough,

Current address: Immuno-Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom

Affiliation The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom
⨯
Darren R. Flower

* E-mail: darren.flower@jenner.ac.uk

Affiliation The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom
⨯

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

Matthew N. Davies,
Jagadeesh Bayry,
Elma Z. Tchilian,
Janakiraman Vani,
Melkote S. Shaila,
Emily K. Forbes,
Simon J. Draper,
Peter C. L. Beverley,
David F. Tough,
Darren R. Flower

Published: November 30, 2009
https://doi.org/10.1371/journal.pone.0008084

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