GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway

Josep M. Lluis; Laura Llacuna; Claudia von Montfort; Cristina Bárcena; Carlos Enrich; Albert Morales; José C. Fernandez-Checa

doi:10.1371/journal.pone.0008059

Loading metrics

Open Access

Peer-reviewed

Research Article

GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway

Josep M. Lluis,

Affiliations Department of Cell Death and Proliferation, IIBB-CSIC, and Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Spain, Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
⨯
Laura Llacuna,

Affiliation Department of Cell Death and Proliferation, IIBB-CSIC, and Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Spain
⨯
Claudia von Montfort,

Affiliation Department of Cell Death and Proliferation, IIBB-CSIC, and Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Spain
⨯
Cristina Bárcena,

Affiliation Department of Cell Death and Proliferation, IIBB-CSIC, and Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Spain
⨯
Carlos Enrich,

Affiliation Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
⨯
Albert Morales ,

Contributed equally to this work with: Albert Morales, José C. Fernandez-Checa

* E-mail: amorales@clinic.ub.es (AM); checa229@yahoo.com (JFC)

Affiliation Department of Cell Death and Proliferation, IIBB-CSIC, and Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Spain
⨯
José C. Fernandez-Checa

Contributed equally to this work with: Albert Morales, José C. Fernandez-Checa

* E-mail: amorales@clinic.ub.es (AM); checa229@yahoo.com (JFC)

Affiliations Department of Cell Death and Proliferation, IIBB-CSIC, and Liver Unit, Hospital Clinic, IDIBAPS-CIBEK, CIBEREHD, Barcelona, Spain, Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America
⨯

GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway

Josep M. Lluis,
Laura Llacuna,
Claudia von Montfort,
Cristina Bárcena,
Carlos Enrich,
Albert Morales,
José C. Fernandez-Checa

Published: November 26, 2009
https://doi.org/10.1371/journal.pone.0008059

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hypoxia
Is the Subject Area "Hypoxia" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Sphingolipids
Is the Subject Area "Sphingolipids" applicable to this article?

Thanks for your feedback.
Cell death
Is the Subject Area "Cell death" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.