Catastrophic NAD⁺ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

• Santina Bruzzone ,

  Contributed equally to this work with: Santina Bruzzone, Floriana Fruscione, Sara Morando

  Affiliation Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy

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• Floriana Fruscione ,

  Contributed equally to this work with: Santina Bruzzone, Floriana Fruscione, Sara Morando

  Affiliation Advanced Biotechnology Center, Genoa, Italy

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• Sara Morando ,

  Contributed equally to this work with: Santina Bruzzone, Floriana Fruscione, Sara Morando

  Affiliation Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy

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• Tiziana Ferrando,

  Affiliation Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy

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• Alessandro Poggi,

  Affiliation Laboratory of Immunology, Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy

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• Anna Garuti,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Agustina D'Urso,

  Affiliation Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Martina Selmo,

  Affiliation Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy

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• Federica Benvenuto,

  Affiliation Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy

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• Michele Cea,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Gabriele Zoppoli,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Eva Moran,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Debora Soncini,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Alberto Ballestrero,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Bernard Sordat,

  Affiliation Laboratory of Glycochemistry and Asymmetric Synthesis, Swiss Federal Institute of Technology (EPFL), Batochime, Lausanne, Switzerland

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• Franco Patrone,

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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• Raul Mostoslavsky,

  Affiliation Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Antonio Uccelli,

  Affiliation Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy

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•  [ ... ],
• Alessio Nencioni

  * E-mail: A.Nencioni@gmx.net

  Affiliation Department of Internal Medicine, University of Genoa, Genoa, Italy

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