Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

Kengo Uemura; Christina M. Lill; Xuejing Li; Jessica A. Peters; Alexander Ivanov; Zhanyun Fan; Bart DeStrooper; Brian J. Bacskai; Bradley T. Hyman; Oksana Berezovska

doi:10.1371/journal.pone.0007893

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Peer-reviewed

Research Article

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β_42/40 Ratio

Kengo Uemura,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Christina M. Lill,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Xuejing Li,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Jessica A. Peters,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Alexander Ivanov,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Zhanyun Fan,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Bart DeStrooper,

Affiliation Laboratory of Neuronal Cell Biology and Gene Transfer, Katholieke Universiteit Leuven, Leuven, Belgium
⨯
Brian J. Bacskai,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Bradley T. Hyman,

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯
Oksana Berezovska

* E-mail: oberezovska@partners.org

Affiliation Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
⨯

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β_42/40 Ratio

Kengo Uemura,
Christina M. Lill,
Xuejing Li,
Jessica A. Peters,
Alexander Ivanov,
Zhanyun Fan,
Bart DeStrooper,
Brian J. Bacskai,
Bradley T. Hyman,
Oksana Berezovska

Published: November 18, 2009
https://doi.org/10.1371/journal.pone.0007893

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