Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

Mathieu Darsigny; Jean-Philippe Babeu; Andrée-Anne Dupuis; Emma E. Furth; Ernest G. Seidman; Émile Lévy; Elena F. Verdu; Fernand-Pierre Gendron; François Boudreau

doi:10.1371/journal.pone.0007609

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Peer-reviewed

Research Article

Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

Mathieu Darsigny,

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
⨯
Jean-Philippe Babeu,

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
⨯
Andrée-Anne Dupuis,

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
⨯
Emma E. Furth,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Ernest G. Seidman,

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Research Institute, McGill University Health Center, Montréal, Quebec, Canada
⨯
Émile Lévy,

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Department of Nutrition, CHU Ste-Justine, Université de Montréal, Quebec, Canada
⨯
Elena F. Verdu,

Affiliation Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
⨯
Fernand-Pierre Gendron,

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
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François Boudreau

* E-mail: Francois.Boudreau@usherbrooke.ca

Affiliations Canadian Institutes of Health Research Team on Digestive Epithelium, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada, Département d'anatomie et biologie cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
⨯

Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

Mathieu Darsigny,
Jean-Philippe Babeu,
Andrée-Anne Dupuis,
Emma E. Furth,
Ernest G. Seidman,
Émile Lévy,
Elena F. Verdu,
Fernand-Pierre Gendron,
François Boudreau

Published: October 29, 2009
https://doi.org/10.1371/journal.pone.0007609

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