A Statistical Model of Protein Sequence Similarity and Function Similarity Reveals Overly-Specific Function Predictions

• Brenton Louie ,

  Contributed equally to this work with: Brenton Louie, Roger Higdon

  Affiliations Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, Predictive Analytics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, United States of America

  ⨯
• Roger Higdon ,

  Contributed equally to this work with: Brenton Louie, Roger Higdon

  Affiliations Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, Predictive Analytics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, United States of America

  ⨯
• Eugene Kolker

  * E-mail: eugene.kolker@seattlechildrens.org

  Affiliations Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute, Seattle, Washington, United States of America, Predictive Analytics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, United States of America, Biomedical and Health Informatics Division, Department of Medical Education and Biomedical Informatics, University of Washington School of Medicine, Seattle, Washington, United States of America

  ⨯