Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases

Open Access

Peer-reviewed

Research Article

Anshuman Dixit,

Affiliations Graduate Program for Bioinformatics, Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America, Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America
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Lin Yi,

Affiliation Graduate Program for Bioinformatics, Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America
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Ragul Gowthaman,

Affiliation Graduate Program for Bioinformatics, Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America
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Ali Torkamani,

Affiliation Scripps Genomic Medicine, Department of Molecular and Experimental Medicine, Scripps Health and The Scripps Research Institute, La Jolla, California, United States of America
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Nicholas J. Schork,

Affiliation Scripps Genomic Medicine, Department of Molecular and Experimental Medicine, Scripps Health and The Scripps Research Institute, La Jolla, California, United States of America
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Gennady M. Verkhivker

* E-mail: verk@ku.edu

Affiliations Graduate Program for Bioinformatics, Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America, Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
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Cancers and neoplasms
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Protein kinases
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Crystal structure
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Carcinogenesis
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Single nucleotide polymorphisms
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Mutation databases
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Point mutation
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Sequence alignment
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