A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Kara J. Johnson; Ian J. Griswold; Thomas O'Hare; Amie S. Corbin; Marc Loriaux; Michael W. Deininger; Brian J. Druker

doi:10.1371/journal.pone.0007439

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Peer-reviewed

Research Article

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Kara J. Johnson ,

* E-mail: johnskar@ohsu.edu

Affiliation Division of Hematology and Medical Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Ian J. Griswold,

Affiliations Division of Hematology and Medical Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America, Howard Hughes Medical Institute, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Thomas O'Hare,

Affiliations Division of Hematology and Medical Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America, Howard Hughes Medical Institute, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Amie S. Corbin,

Affiliations Division of Hematology and Medical Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America, Howard Hughes Medical Institute, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Marc Loriaux,

Affiliation Department of Pathology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Michael W. Deininger,

Affiliation Division of Hematology and Medical Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America
⨯
Brian J. Druker

Affiliations Division of Hematology and Medical Oncology, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America, Howard Hughes Medical Institute, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon, United States of America
⨯

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Kara J. Johnson,
Ian J. Griswold,
Thomas O'Hare,
Amie S. Corbin,
Marc Loriaux,
Michael W. Deininger,
Brian J. Druker

Published: October 13, 2009
https://doi.org/10.1371/journal.pone.0007439

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