Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

Geoffrey W. Stone; Suzanne Barzee; Victoria Snarsky; Camila Santucci; Brian Tran; Robert Langer; Gregory T. Zugates; Daniel G. Anderson; Richard S. Kornbluth

doi:10.1371/journal.pone.0007334

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Open Access

Peer-reviewed

Research Article

Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

Geoffrey W. Stone,

Current address: Miller School of Medicine, University of Miami, Miami, Florida, United States of America

Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, VA San Diego Healthcare System, La Jolla, California, United States of America
⨯
Suzanne Barzee,

Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, VA San Diego Healthcare System, La Jolla, California, United States of America
⨯
Victoria Snarsky,

Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, VA San Diego Healthcare System, La Jolla, California, United States of America
⨯
Camila Santucci,

Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, VA San Diego Healthcare System, La Jolla, California, United States of America
⨯
Brian Tran,

Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, VA San Diego Healthcare System, La Jolla, California, United States of America
⨯
Robert Langer,

Affiliations David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, United States of America, Chemical Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Gregory T. Zugates,

Affiliation David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, United States of America
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Daniel G. Anderson,

Affiliation David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, United States of America
⨯
Richard S. Kornbluth

* E-mail: rkornbluth@ucsd.edu

Current address: Multimeric Biotherapeutics, Inc., La Jolla, California, United States of America

Affiliations Department of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, VA San Diego Healthcare System, La Jolla, California, United States of America
⨯

Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

Geoffrey W. Stone,
Suzanne Barzee,
Victoria Snarsky,
Camila Santucci,
Brian Tran,
Robert Langer,
Gregory T. Zugates,
Daniel G. Anderson,
Richard S. Kornbluth

Published: October 8, 2009
https://doi.org/10.1371/journal.pone.0007334

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