Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

Karine H. Hellemans; Jean-Claude Hannaert; Bart Denys; Knut R. Steffensen; Cindy Raemdonck; Geert A. Martens; Paul P. Van Veldhoven; Jan-Åke Gustafsson; Daniel Pipeleers

doi:10.1371/journal.pone.0007266

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Open Access

Peer-reviewed

Research Article

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

Karine H. Hellemans ,

* E-mail: karine.hellemans@vub.ac.be

Affiliation Diabetes Research Center, Brussels Free University-VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
⨯
Jean-Claude Hannaert,

Affiliation Diabetes Research Center, Brussels Free University-VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
⨯
Bart Denys,

Affiliation Diabetes Research Center, Brussels Free University-VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
⨯
Knut R. Steffensen,

Affiliation Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Stockholm, Sweden
⨯
Cindy Raemdonck,

Affiliation Diabetes Research Center, Brussels Free University-VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
⨯
Geert A. Martens,

Affiliation Diabetes Research Center, Brussels Free University-VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
⨯
Paul P. Van Veldhoven,

Affiliation LIPIT, Departement Moleculaire Celbiologie, Katholieke Universiteit Leuven-KUL, Leuven, Belgium
⨯
Jan-Åke Gustafsson,

Affiliations Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Stockholm, Sweden, Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Houston, Texas, United States of America
⨯
Daniel Pipeleers

Affiliation Diabetes Research Center, Brussels Free University-VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
⨯

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

Karine H. Hellemans,
Jean-Claude Hannaert,
Bart Denys,
Knut R. Steffensen,
Cindy Raemdonck,
Geert A. Martens,
Paul P. Van Veldhoven,
Jan-Åke Gustafsson,
Daniel Pipeleers

Published: September 29, 2009
https://doi.org/10.1371/journal.pone.0007266

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Fatty acids
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