Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

Ikechukwu Okoli; Jeffrey J. Coleman; Emmanouil Tempakakis; W. Frank An; Edward Holson; Florence Wagner; Annie L. Conery; Jonah Larkins-Ford; Gang Wu; Andy Stern; Frederick M. Ausubel; Eleftherios Mylonakis

doi:10.1371/journal.pone.0007025

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Peer-reviewed

Research Article

Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

Ikechukwu Okoli,

Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jeffrey J. Coleman,

Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Emmanouil Tempakakis,

Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
W. Frank An,

Affiliation Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, United States of America
⨯
Edward Holson,

Affiliation Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, United States of America
⨯
Florence Wagner,

Affiliation Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, United States of America
⨯
Annie L. Conery,

Affiliation Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jonah Larkins-Ford,

Affiliation Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Gang Wu,

Affiliation Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Andy Stern,

Affiliation Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, United States of America
⨯
Frederick M. Ausubel,

Affiliation Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Eleftherios Mylonakis

* E-mail: emylonakis@partners.org

Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯

Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

Ikechukwu Okoli,
Jeffrey J. Coleman,
Emmanouil Tempakakis,
W. Frank An,
Edward Holson,
Florence Wagner,
Annie L. Conery,
Jonah Larkins-Ford,
Gang Wu,
Andy Stern

Published: September 14, 2009
https://doi.org/10.1371/journal.pone.0007025

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