Insulin Gene Expression Is Regulated by DNA Methylation

Akio Kuroda; Tibor A. Rauch; Ivan Todorov; Hsun Teresa Ku; Ismail H. Al-Abdullah; Fouad Kandeel; Yoko Mullen; Gerd P. Pfeifer; Kevin Ferreri

doi:10.1371/journal.pone.0006953

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Open Access

Peer-reviewed

Research Article

Insulin Gene Expression Is Regulated by DNA Methylation

Akio Kuroda,

Current address: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita-City, Japan

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯
Tibor A. Rauch,

Current address: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America

Affiliation Department of Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Ivan Todorov,

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯
Hsun Teresa Ku,

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯
Ismail H. Al-Abdullah,

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯
Fouad Kandeel,

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯
Yoko Mullen,

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯
Gerd P. Pfeifer,

Affiliation Department of Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Kevin Ferreri

* E-mail: kferreri@coh.org

Affiliation Department of Diabetes, Endocrinology, & Metabolism, Research Institute of City of Hope, Duarte, California, United States of America
⨯

Insulin Gene Expression Is Regulated by DNA Methylation

Akio Kuroda,
Tibor A. Rauch,
Ivan Todorov,
Hsun Teresa Ku,
Ismail H. Al-Abdullah,
Fouad Kandeel,
Yoko Mullen,
Gerd P. Pfeifer,
Kevin Ferreri

Published: September 9, 2009
https://doi.org/10.1371/journal.pone.0006953

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DNA methylation
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Insulin
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Gene expression
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Cell differentiation
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Mammalian genomics
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Transfection
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DNA transcription
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DNA-binding proteins
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