Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target

Paul Gratraud; Enlli Huws; Brie Falkard; Sophie Adjalley; David A. Fidock; Laurence Berry; William R. Jacobs Jr.; Mark S. Baird; Henri Vial; Laurent Kremer

doi:10.1371/journal.pone.0006889

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Peer-reviewed

Research Article

Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target

Paul Gratraud,

Affiliation Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, case 107, Montpellier, France
⨯
Enlli Huws,

Affiliation School of Chemistry, Bangor University, Bangor, Wales
⨯
Brie Falkard,

Affiliation Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
⨯
Sophie Adjalley,

Affiliation Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
⨯
David A. Fidock,

Affiliations Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
⨯
Laurence Berry,

Affiliation Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, case 107, Montpellier, France
⨯
William R. Jacobs Jr.,

Affiliations Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Mark S. Baird,

Affiliation School of Chemistry, Bangor University, Bangor, Wales
⨯
Henri Vial,

Affiliations Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, case 107, Montpellier, France, INSERM, DIMNP, Montpellier, France
⨯
Laurent Kremer

* E-mail: laurent.kremer@univ-montp2.fr

Affiliations Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, case 107, Montpellier, France, INSERM, DIMNP, Montpellier, France
⨯

Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target

Paul Gratraud,
Enlli Huws,
Brie Falkard,
Sophie Adjalley,
David A. Fidock,
Laurence Berry,
William R. Jacobs Jr.,
Mark S. Baird,
Henri Vial,
Laurent Kremer

Published: September 3, 2009
https://doi.org/10.1371/journal.pone.0006889

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Plasmodium
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Oleic acid
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Chemical synthesis
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Thin-layer chromatography
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Fatty acids
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