Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program

Marijana Radonjic; Jorn R. de Haan; Marjan J. van Erk; Ko Willems van Dijk; Sjoerd A. A. van den Berg; Philip J. de Groot; Michael Müller; Ben van Ommen

doi:10.1371/journal.pone.0006646

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Peer-reviewed

Research Article

Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program

Marijana Radonjic ,

* E-mail: marijana.radonjic@tno.nl

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, TNO Quality of Life, BU Biosciences, Zeist, The Netherlands
⨯
Jorn R. de Haan,

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, TNO Quality of Life, BU Biosciences, Zeist, The Netherlands
⨯
Marjan J. van Erk,

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, TNO Quality of Life, BU Biosciences, Zeist, The Netherlands
⨯
Ko Willems van Dijk,

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, Departments of General Internal Medicine and Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Sjoerd A. A. van den Berg,

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, Departments of General Internal Medicine and Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Philip J. de Groot,

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, Department of Human Nutrition, Wageningen UR, Wageningen, The Netherlands
⨯
Michael Müller,

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, Department of Human Nutrition, Wageningen UR, Wageningen, The Netherlands
⨯
Ben van Ommen

Affiliations Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands, TNO Quality of Life, BU Biosciences, Zeist, The Netherlands
⨯

Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program

Marijana Radonjic,
Jorn R. de Haan,
Marjan J. van Erk,
Ko Willems van Dijk,
Sjoerd A. A. van den Berg,
Philip J. de Groot,
Michael Müller,
Ben van Ommen

Published: August 14, 2009
https://doi.org/10.1371/journal.pone.0006646

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Diet
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Gene expression
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Inflammation
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Transcription factors
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Fats
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Immune response
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Steatosis
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Metabolic syndrome
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