Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

Wendy R. Gordon; Didem Vardar-Ulu; Sarah L'Heureux; Todd Ashworth; Michael J. Malecki; Cheryll Sanchez-Irizarry; Debbie G. McArthur; Gavin Histen; Jennifer L. Mitchell; Jon C. Aster; Stephen C. Blacklow

doi:10.1371/journal.pone.0006613

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Peer-reviewed

Research Article

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

Wendy R. Gordon,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Didem Vardar-Ulu,

Affiliation Department of Chemistry, Wellesley College, Wellesley, Massachusetts, United States of America
⨯
Sarah L'Heureux,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Todd Ashworth,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael J. Malecki,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Cheryll Sanchez-Irizarry,

Current address: Genentech, Inc., South San Francisco, California, United States of America

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Debbie G. McArthur,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Gavin Histen,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jennifer L. Mitchell,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jon C. Aster,

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Stephen C. Blacklow

* E-mail: sblacklow@rics.bwh.harvard.edu

Affiliation Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

Wendy R. Gordon,
Didem Vardar-Ulu,
Sarah L'Heureux,
Todd Ashworth,
Michael J. Malecki,
Cheryll Sanchez-Irizarry,
Debbie G. McArthur,
Gavin Histen,
Jennifer L. Mitchell,
Jon C. Aster

Published: August 24, 2009
https://doi.org/10.1371/journal.pone.0006613

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Flow cytometry
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Insertion mutation
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