Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

George J. Cerniglia; Nabendu Pore; Jeff H. Tsai; Susan Schultz; Rosemarie Mick; Regine Choe; Xiaoman Xing; Turgut Durduran; Arjun G. Yodh; Sydney M. Evans; Cameron J. Koch; Stephen M. Hahn; Harry Quon; Chandra M. Sehgal; William M. F. Lee; Amit Maity

doi:10.1371/journal.pone.0006539

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Peer-reviewed

Research Article

Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

George J. Cerniglia ,

Contributed equally to this work with: George J. Cerniglia, Nabendu Pore

Affiliation Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Nabendu Pore ,

Contributed equally to this work with: George J. Cerniglia, Nabendu Pore

Affiliation Medimmune LLC, Gaithersburg, Maryland, United States of America
⨯
Jeff H. Tsai,

Affiliation Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
⨯
Susan Schultz,

Affiliation Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Rosemarie Mick,

Affiliation Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Regine Choe,

Affiliation Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Xiaoman Xing,

Affiliation Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Turgut Durduran,

Affiliation Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Arjun G. Yodh,

Affiliation Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Sydney M. Evans,

Affiliation Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Cameron J. Koch,

Affiliation Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Stephen M. Hahn,

Affiliation Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Harry Quon,

Affiliation Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Chandra M. Sehgal,

Affiliation Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
William M. F. Lee,

Affiliation Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
[ ... ],
Amit Maity

* E-mail: maity@xrt.upenn.edu

Affiliation Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
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Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

George J. Cerniglia,
Nabendu Pore,
Jeff H. Tsai,
Susan Schultz,
Rosemarie Mick,
Regine Choe,
Xiaoman Xing,
Turgut Durduran,
Arjun G. Yodh,
Sydney M. Evans

Published: August 6, 2009
https://doi.org/10.1371/journal.pone.0006539

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