Association between Protective and Deleterious HLA Alleles with Multiple Sclerosis in Central East Sardinia

Roberta Pastorino; Cristina Menni; Monserrata Barca; Luisa Foco; Valeria Saddi; Giovanna Gazzaniga; Raffaela Ferrai; Luca Mascaretti; Frank Dudbridge; Carlo Berzuini; Salvatore Bruno Murgia; Maria Luisa Piras; Anna Ticca; Pier Paolo Bitti; Luisa Bernardinelli

doi:10.1371/journal.pone.0006526

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Open Access

Peer-reviewed

Research Article

Association between Protective and Deleterious HLA Alleles with Multiple Sclerosis in Central East Sardinia

Roberta Pastorino ,

* E-mail: roberta.pastorino@unipv.it

Affiliation Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali, Università di Pavia, Pavia, Italy
⨯
Cristina Menni,

Affiliations Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali, Università di Pavia, Pavia, Italy, Dipartimento di Statistica, Università di Milano Bicocca, Milano, Italy
⨯
Monserrata Barca,

Affiliation Centro di Tipizzazione Tissutale, S.I.T., Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Luisa Foco,

Affiliation Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali, Università di Pavia, Pavia, Italy
⨯
Valeria Saddi,

Affiliation Divisione di Neurologia, Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Giovanna Gazzaniga,

Affiliation Centro di Tipizzazione Tissutale, S.I.T., Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Raffaela Ferrai,

Affiliation Divisione di Neurologia, Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Luca Mascaretti,

Affiliation Blood Transfusion Centre, San Gerardo Hospital, Monza, Italy
⨯
Frank Dudbridge,

Affiliation MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom
⨯
Carlo Berzuini,

Affiliations MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom, Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge, United Kingdom
⨯
Salvatore Bruno Murgia,

Affiliation Divisione di Neurologia, Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Maria Luisa Piras,

Affiliation Divisione di Neurologia, Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Anna Ticca,

Affiliation Divisione di Neurologia, Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Pier Paolo Bitti,

Affiliation Centro di Tipizzazione Tissutale, S.I.T., Presidio Ospedaliero S. Francesco, ASL N°3, Nuoro, Italy
⨯
Luisa Bernardinelli

Affiliations Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali, Università di Pavia, Pavia, Italy, MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom, Department of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge, United Kingdom
⨯

Association between Protective and Deleterious HLA Alleles with Multiple Sclerosis in Central East Sardinia

Roberta Pastorino,
Cristina Menni,
Monserrata Barca,
Luisa Foco,
Valeria Saddi,
Giovanna Gazzaniga,
Raffaela Ferrai,
Luca Mascaretti,
Frank Dudbridge,
Carlo Berzuini

Published: August 5, 2009
https://doi.org/10.1371/journal.pone.0006526

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Haplotypes
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Multiple sclerosis
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Single nucleotide polymorphisms
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Immune response
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Linkage disequilibrium
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Major histocompatibility complex
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