Characterization of Whole Blood Gene Expression Profiles as a Sequel to Globin mRNA Reduction in Patients with Sickle Cell Disease

Open Access

Peer-reviewed

Research Article

Nalini Raghavachari ,

* E-mail: nraghavachari@nhlbi.nih.gov

Affiliations Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America, National Heart Lung and Blood Institute (NHLBI) Genomics Core Facility, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America
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Xiuli Xu,

Affiliations Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America, National Heart Lung and Blood Institute (NHLBI) Genomics Core Facility, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America
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Peter J. Munson,

Affiliation Mathematical and Statistical Computing Lab, Division of Computational Biosciences, Center for Information Technology, NIH, Maryland, United States of America
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Mark T. Gladwin

Affiliation Pulmonary, Allergy and Critical Care Medicine and Hemostasis and Vascular Biology Research Institute in University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Globins
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Blood
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Gene expression
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Microarrays
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Sickle cell disease
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Gene regulation
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RNA hybridization
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Red blood cells
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