Coupled Stochastic Spatial and Non-Spatial Simulations of ErbB1 Signaling Pathways Demonstrate the Importance of Spatial Organization in Signal Transduction

• Michelle N. Costa,

  Affiliation Department of Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, New Mexico, United States of America

  ⨯
• Krishnan Radhakrishnan,

  Affiliations Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America

  ⨯
• Bridget S. Wilson,

  Affiliations Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America

  ⨯
• Dionisios G. Vlachos,

  Affiliation Department of Chemical Engineering, University of Delaware, Newark, Delaware, United States of America

  ⨯
• Jeremy S. Edwards

  * E-mail: jsedwards@salud.unm.edu

  Affiliations Department of Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, New Mexico, United States of America, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America, Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America

  ⨯