Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation

Open Access

Peer-reviewed

Research Article

Dinesh C. Soares ,

* E-mail: Dinesh.Soares@ed.ac.uk (DCS); C.Abbott@ed.ac.uk (CMA)

Affiliations Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom, School of Chemistry, University of Edinburgh, Edinburgh, United Kingdom
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Paul N. Barlow,

Affiliations School of Chemistry, University of Edinburgh, Edinburgh, United Kingdom, Centre for Translational and Chemical Biology, University of Edinburgh, Edinburgh, United Kingdom
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Helen J. Newbery,

Affiliation Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
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David J. Porteous,

Affiliation Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
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Catherine M. Abbott

* E-mail: Dinesh.Soares@ed.ac.uk (DCS); C.Abbott@ed.ac.uk (CMA)

Affiliation Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
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Elongation factors
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Yeast
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Phosphorylation
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Crystal structure
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Saccharomyces cerevisiae
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Sequence alignment
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Yeast and fungal models
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Mutagenesis
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