Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

Claus Aagaard; Truc Thi Kim Thanh Hoang; Angelo Izzo; Rolf Billeskov; JoLynn Troudt; Kim Arnett; Andrew Keyser; Tara Elvang; Peter Andersen; Jes Dietrich

doi:10.1371/journal.pone.0005930

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Open Access

Peer-reviewed

Research Article

Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

Claus Aagaard ,

Contributed equally to this work with: Claus Aagaard, Truc Thi Kim Thanh Hoang

Affiliation Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
⨯
Truc Thi Kim Thanh Hoang ,

Contributed equally to this work with: Claus Aagaard, Truc Thi Kim Thanh Hoang

Affiliation Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
⨯
Angelo Izzo,

Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Rolf Billeskov,

Affiliation Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
⨯
JoLynn Troudt,

Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Kim Arnett,

Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Andrew Keyser,

Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Tara Elvang,

Affiliation Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
⨯
Peter Andersen,

Affiliation Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
⨯
Jes Dietrich

* E-mail: JDI@ssi.dk

Affiliation Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
⨯

Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

Claus Aagaard,
Truc Thi Kim Thanh Hoang,
Angelo Izzo,
Rolf Billeskov,
JoLynn Troudt,
Kim Arnett,
Andrew Keyser,
Tara Elvang,
Peter Andersen,
Jes Dietrich

Published: June 16, 2009
https://doi.org/10.1371/journal.pone.0005930

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