The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

Timothy R. D. J. Radstake; Lenny van Bon; Jasper Broen; Anila Hussiani; Roger Hesselstrand; Dirk M. Wuttge; Yanhui Deng; Robbert Simms; Erik Lubberts; Robert Lafyatis

doi:10.1371/journal.pone.0005903

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Open Access

Peer-reviewed

Research Article

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

Timothy R. D. J. Radstake ,

Contributed equally to this work with: Timothy R. D. J. Radstake, Lenny van Bon

* E-mail: tradstake73@gmail.com

Affiliations Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands, The Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Lenny van Bon ,

Contributed equally to this work with: Timothy R. D. J. Radstake, Lenny van Bon

Affiliations Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands, The Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Jasper Broen,

Affiliations Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands, The Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Anila Hussiani,

Affiliation The Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Roger Hesselstrand,

Affiliation Department of Rheumatology, Lund University Hospital, Lund, Sweden
⨯
Dirk M. Wuttge,

Affiliation Department of Rheumatology, Lund University Hospital, Lund, Sweden
⨯
Yanhui Deng,

Affiliation BUMC Flow Cytometry Core Facility, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Robbert Simms,

Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
⨯
Erik Lubberts,

Affiliation Erasmus MC, Departments of Immunology and Rheumatology, University Medical Center Rotterdam, Rotterdam, The Netherlands
⨯
Robert Lafyatis

Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
⨯

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

Timothy R. D. J. Radstake,
Lenny van Bon,
Jasper Broen,
Anila Hussiani,
Roger Hesselstrand,
Dirk M. Wuttge,
Yanhui Deng,
Robbert Simms,
Erik Lubberts,
Robert Lafyatis

Published: June 17, 2009
https://doi.org/10.1371/journal.pone.0005903

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