Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion

Yi Fu; Wei Tian; Emily B. Pratt; Lisa B. Dirling; Show-Ling Shyng; Charles K. Meshul; David M. Cohen

doi:10.1371/journal.pone.0005679

Loading metrics

Open Access

Peer-reviewed

Research Article

Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion

Yi Fu,

Affiliations Division of Nephrology & Hypertension, Departments of Medicine, Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon, United States of America, The Research Service, Portland V.A. Medical Center, Portland, Oregon, United States of America
⨯
Wei Tian,

Affiliations Division of Nephrology & Hypertension, Departments of Medicine, Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon, United States of America, The Research Service, Portland V.A. Medical Center, Portland, Oregon, United States of America
⨯
Emily B. Pratt,

Affiliations Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, United States of America, Center for Research in Occupational and Environmental Toxicity, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Lisa B. Dirling,

Affiliations Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, United States of America, Department of Pathology, Oregon Health & Science University, Portland, Oregon, United States of America, The Research Service, Portland V.A. Medical Center, Portland, Oregon, United States of America
⨯
Show-Ling Shyng,

Affiliations Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon, United States of America, Center for Research in Occupational and Environmental Toxicity, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Charles K. Meshul,

Affiliations Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, United States of America, Department of Pathology, Oregon Health & Science University, Portland, Oregon, United States of America, The Research Service, Portland V.A. Medical Center, Portland, Oregon, United States of America
⨯
David M. Cohen

* E-mail: cohend@ohsu.edu

Affiliations Division of Nephrology & Hypertension, Departments of Medicine, Cell and Developmental Biology, Oregon Health & Science University, Portland, Oregon, United States of America, The Research Service, Portland V.A. Medical Center, Portland, Oregon, United States of America
⨯

Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion

Yi Fu,
Wei Tian,
Emily B. Pratt,
Lisa B. Dirling,
Show-Ling Shyng,
Charles K. Meshul,
David M. Cohen

Published: May 25, 2009
https://doi.org/10.1371/journal.pone.0005679

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Insulin secretion
Is the Subject Area "Insulin secretion" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Vesicles
Is the Subject Area "Vesicles" applicable to this article?

Thanks for your feedback.
Zinc
Is the Subject Area "Zinc" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Zinc transporters
Is the Subject Area "Zinc transporters" applicable to this article?

Thanks for your feedback.