TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA

• Hiroyasu Konno,

  Affiliation Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Takuya Yamamoto,

  Affiliations Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan

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• Kohsuke Yamazaki,

  Affiliation Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Jin Gohda,

  Affiliation Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Taishin Akiyama,

  Affiliation Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Kentaro Semba,

  Affiliation Department of Life Science and Medical Bio-Science, Waseda University, Tokyo, Japan

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• Hideo Goto,

  Affiliation Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Atsushi Kato,

  Affiliation Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan

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• Toshiaki Yujiri,

  Affiliation Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan

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• Takahiko Imai,

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Yasushi Kawaguchi,

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Bing Su,

  Affiliation Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Osamu Takeuchi,

  Affiliation Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka, Japan

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• Shizuo Akira,

  Affiliation Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka, Japan

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• Yasuko Tsunetsugu-Yokota,

  Affiliation Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan

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•  [ ... ],
• Jun-ichiro Inoue

  * E-mail: jun-i@ims.u-tokyo.ac.jp

  Affiliation Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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