Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

Daniel V. Correia; Francisco d'Orey; Bruno A. Cardoso; Telma Lança; Ana R. Grosso; Ana deBarros; Leila R. Martins; João T. Barata; Bruno Silva-Santos

doi:10.1371/journal.pone.0005657

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Peer-reviewed

Research Article

Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

Daniel V. Correia ,

Contributed equally to this work with: Daniel V. Correia, Francisco d'Orey

Affiliations Molecular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Francisco d'Orey ,

Contributed equally to this work with: Daniel V. Correia, Francisco d'Orey

Affiliations Molecular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Bruno A. Cardoso,

Affiliation Cancer Biology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
Telma Lança,

Affiliations Molecular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Ana R. Grosso,

Affiliation Cellular Biology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
Ana deBarros,

Affiliations Molecular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Leila R. Martins,

Affiliation Cancer Biology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
João T. Barata,

Affiliation Cancer Biology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
⨯
Bruno Silva-Santos

* E-mail: bsilvasantos@gmail.com

Affiliations Molecular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯

Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

Daniel V. Correia,
Francisco d'Orey,
Bruno A. Cardoso,
Telma Lança,
Ana R. Grosso,
Ana deBarros,
Leila R. Martins,
João T. Barata,
Bruno Silva-Santos

Published: May 21, 2009
https://doi.org/10.1371/journal.pone.0005657

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