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Open Access

Peer-reviewed

Research Article

The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties

Kim Monkhorst ,

Contributed equally to this work with: Kim Monkhorst, Bas de Hoon

Affiliations Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands, Department of Cell Biology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯
Bas de Hoon ,

Contributed equally to this work with: Kim Monkhorst, Bas de Hoon

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯
Iris Jonkers,

Affiliations Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands, Department of Cell Biology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯
Eskeatnaf Mulugeta Achame,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
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Wouter Monkhorst,

Affiliation Code-B Internet Applications, Delft, the Netherlands
⨯
Jos Hoogerbrugge,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯
Eveline Rentmeester,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
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Hans V. Westerhoff,

Affiliations Department of Molecular Cell Physiology, Free University Amsterdam, Amsterdam, the Netherlands, Manchester Centre for Integrative Systems Biology, Manchester, United Kingdom
⨯
Frank Grosveld,

Affiliation Department of Cell Biology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯
J. Anton Grootegoed,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯
Joost Gribnau

* E-mail: j.gribnau@erasmusmc.nl

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
⨯

The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties

Kim Monkhorst,
Bas de Hoon,
Iris Jonkers,
Eskeatnaf Mulugeta Achame,
Wouter Monkhorst,
Jos Hoogerbrugge,
Eveline Rentmeester,
Hans V. Westerhoff,
Frank Grosveld,
J. Anton Grootegoed

x

Published: May 19, 2009
https://doi.org/10.1371/journal.pone.0005616

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Cell differentiation
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X chromosome inactivation
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Triploidy
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X chromosomes
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Spermatids
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Cell cycle and cell division
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Tetraploidy
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Cell fusion
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