Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice

Wenrui Duan; Li Gao; Xin Wu; Erinn M. Hade; Jian-Xin Gao; Haiming Ding; Sanford H. Barsky; Gregory A. Otterson; Miguel A. Villalona-Calero

doi:10.1371/journal.pone.0005563

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Peer-reviewed

Research Article

Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice

Wenrui Duan ,

* E-mail: Wenrui.duan@osumc.edu (WD); miguel.villalona@osumc.edu (MAV-C)

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Li Gao,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Xin Wu,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Erinn M. Hade,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, The Center for Biostatistics, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Jian-Xin Gao,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Pathology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Haiming Ding,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Radiology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Sanford H. Barsky,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Pathology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Gregory A. Otterson,

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯
Miguel A. Villalona-Calero

* E-mail: Wenrui.duan@osumc.edu (WD); miguel.villalona@osumc.edu (MAV-C)

Affiliations Comprehensive Cancer Center, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America, Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, United States of America
⨯

Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice

Wenrui Duan,
Li Gao,
Xin Wu,
Erinn M. Hade,
Jian-Xin Gao,
Haiming Ding,
Sanford H. Barsky,
Gregory A. Otterson,
Miguel A. Villalona-Calero

Published: May 15, 2009
https://doi.org/10.1371/journal.pone.0005563

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Lung and intrathoracic tumors
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Secondary lung tumors
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Adenocarcinoma of the lung
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Genetically modified animals
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Mouse models
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Non-small cell lung cancer
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DNA methylation
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Point mutation
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